7 research outputs found
Theory and simulation of ultra-high-temperature ceramics
At Imperial College our group contributes theory and simulation advances to the Materials for Extreme Environments (XMat) project. Our research supports experiment and industry by developing and applying new high-temperature modelling techniques. These techniques are broad-ranging, from CALPHAD and DFT, to interatomic potentials and analytic models. Here we present advances on each approach and re-cover highlights including:
- the release of MEAMfit, the interatomic potential fitting code
- the development of the TU-TILD approach, for fast and full-order anharmonic thermodynamics [1]
- a new first-principles-assisted CALPHAD assessment of ZrC
- analytic models of strain and anharmonicity in carbides and borides
- ab initio prediction of intrinsic defects at ultra-high temperatures
- first principles heat and charge transport predictions for carbides
Further, we summarise ongoing developments from the theory and simulation group, such as on first principles MAX phase thermodynamics
Please click Additional Files below to see the full abstract
An Agent-Based Model Framework for Utility-Based Cryptoeconomies
In this paper, we outline a framework for modeling utility-based
blockchain-enabled economic systems using Agent Based Modeling (ABM). Our
approach is to model the supply dynamics based on metrics of the cryptoeconomy.
We then build autonomous agents that make decisions based on those metrics.
Those decisions, in turn, impact the metrics in the next time-step, creating a
closed loop that models the evolution of cryptoeconomies over time. We apply
this framework as a case-study to Filecoin, a decentralized blockchain-based
storage network. We perform several experiments that explore the effect of
different strategies, capitalization, and external factors to agent rewards,
that highlight the efficacy of our approach to modeling blockchain based
cryptoeconomies.Comment: 14 pages, 5 figure
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion
Abstract: The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) and B.1.1.7 (Alpha)1. In vitro, B.1.617.2 is sixfold less sensitive to serum neutralizing antibodies from recovered individuals, and eightfold less sensitive to vaccine-elicited antibodies, compared with wild-type Wuhan-1 bearing D614G. Serum neutralizing titres against B.1.617.2 were lower in ChAdOx1 vaccinees than in BNT162b2 vaccinees. B.1.617.2 spike pseudotyped viruses exhibited compromised sensitivity to monoclonal antibodies to the receptor-binding domain and the amino-terminal domain. B.1.617.2 demonstrated higher replication efficiency than B.1.1.7 in both airway organoid and human airway epithelial systems, associated with B.1.617.2 spike being in a predominantly cleaved state compared with B.1.1.7 spike. The B.1.617.2 spike protein was able to mediate highly efficient syncytium formation that was less sensitive to inhibition by neutralizing antibody, compared with that of wild-type spike. We also observed that B.1.617.2 had higher replication and spike-mediated entry than B.1.617.1, potentially explaining the B.1.617.2 dominance. In an analysis of more than 130 SARS-CoV-2-infected health care workers across three centres in India during a period of mixed lineage circulation, we observed reduced ChAdOx1 vaccine effectiveness against B.1.617.2 relative to non-B.1.617.2, with the caveat of possible residual confounding. Compromised vaccine efficacy against the highly fit and immune-evasive B.1.617.2 Delta variant warrants continued infection control measures in the post-vaccination era
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion.
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) and B.1.1.7 (Alpha)1. In vitro, B.1.617.2 is sixfold less sensitive to serum neutralizing antibodies from recovered individuals, and eightfold less sensitive to vaccine-elicited antibodies, compared with wild-type Wuhan-1 bearing D614G. Serum neutralizing titres against B.1.617.2 were lower in ChAdOx1 vaccinees than in BNT162b2 vaccinees. B.1.617.2 spike pseudotyped viruses exhibited compromised sensitivity to monoclonal antibodies to the receptor-binding domain and the amino-terminal domain. B.1.617.2 demonstrated higher replication efficiency than B.1.1.7 in both airway organoid and human airway epithelial systems, associated with B.1.617.2 spike being in a predominantly cleaved state compared with B.1.1.7 spike. The B.1.617.2 spike protein was able to mediate highly efficient syncytium formation that was less sensitive to inhibition by neutralizing antibody, compared with that of wild-type spike. We also observed that B.1.617.2 had higher replication and spike-mediated entry than B.1.617.1, potentially explaining the B.1.617.2 dominance. In an analysis of more than 130 SARS-CoV-2-infected health care workers across three centres in India during a period of mixed lineage circulation, we observed reduced ChAdOx1 vaccine effectiveness against B.1.617.2 relative to non-B.1.617.2, with the caveat of possible residual confounding. Compromised vaccine efficacy against the highly fit and immune-evasive B.1.617.2 Delta variant warrants continued infection control measures in the post-vaccination era
LibraryCarpentry/lc-shell: Library Carpentry: Introduction to the Shell for librarians, June 2019
Library Carpentry lesson to learn how to use the Shell
swcarpentry/shell-novice: Software Carpentry: the UNIX shell, June 2019
Software Carpentry lesson on how to use the shell to navigate the filesystem and write simple loops and scripts